HER2 Support Group Forums - View Single Post - Tykerb & Her2 signaling pathways explained

1rarebird · 06-17-2010, 11:38 AM

There is both frightening and encouraging information on the high risks associated with a Her2+ diagnosis in this paper---particularly when it comes to CNS or brain metastases. Even though the paper was apparently mainly funded by GSK and is possibly biased to some degree, it gives a strong rationale for the use of lapatinib, Tykerb, in the management of the disease-- again, particularly in CNS metastasis settings. IMHO, I believe the hour or two needed to read the paper and many of its extensive references is time well spent. Well, it was for me anyway.

bird

06-17-2010, 11:38 AM	#2
1rarebird Senior Member Join Date: Feb 2010 Location: TN Posts: 175	Re: Tykerb & Her2 signaling pathways explained There is both frightening and encouraging information on the high risks associated with a Her2+ diagnosis in this paper---particularly when it comes to CNS or brain metastases. Even though the paper was apparently mainly funded by GSK and is possibly biased to some degree, it gives a strong rationale for the use of lapatinib, Tykerb, in the management of the disease-- again, particularly in CNS metastasis settings. IMHO, I believe the hour or two needed to read the paper and many of its extensive references is time well spent. Well, it was for me anyway. bird __________________ Male Breast Cancer, DX 5/15/09, IDC, STAGE 1, 1.7 cm, HER2+++, ER+(95%)/PR+(75%), Ki67 40%, grade 3, 0/5 nodes, TX: mastectomy, TCH finished 7/19/10, radiation 6 wks., Tamoxifen on going, bisphosphonate 24 mos.