HER2 Support Group Forums - View Single Post - why targetting just one oncogene may fail

Hopeful · 02-22-2007, 02:23 PM

AlaskaAngel,

This is one of my greatest concerns about chemotherapy and Her2. It seems to me highly mutagenic and I think often less is more. I have been intriguied by the descriptions of metronomic chemo, given low dose (below the toxic level) but sustained to knock out the cancer cells. The approach makes more sense to me from the git-go than giving toxic doses of these drugs with "breathers" in between for the healthy cells to recover and very possibly the cancer cells that are not knocked out in that treatment to figure out a way to survive the rest of them. Unfortunately, no one would do a clinical test of metronomic chemo in early stage bc patients, I guess it is counter-intuitive to the medical mind. If it was offered, this is something I would have seriously considered.

Hopeful

02-22-2007, 02:23 PM	#3
Hopeful Senior Member Join Date: Aug 2006 Posts: 3,380	Excellent question AlaskaAngel, This is one of my greatest concerns about chemotherapy and Her2. It seems to me highly mutagenic and I think often less is more. I have been intriguied by the descriptions of metronomic chemo, given low dose (below the toxic level) but sustained to knock out the cancer cells. The approach makes more sense to me from the git-go than giving toxic doses of these drugs with "breathers" in between for the healthy cells to recover and very possibly the cancer cells that are not knocked out in that treatment to figure out a way to survive the rest of them. Unfortunately, no one would do a clinical test of metronomic chemo in early stage bc patients, I guess it is counter-intuitive to the medical mind. If it was offered, this is something I would have seriously considered. Hopeful