HER2 Support Group Forums - View Single Post - From the NEJM: Comparative Effectiveness Questions in Oncology

gdpawel · 04-17-2014, 08:15 PM

One good example of Comparative Effectiveness Research in cancer medicine was a Duke University cost savings study on the impact of a chemoresponse assay on treatment costs for recurrent ovarian cancer. They sought to estimate mean costs of chemotherapy treatment with or without use of a chemoresponse assay.

They estimated mean costs for 3 groups: (1) assay assisted: 75 women who received oncologist's choice of chemotherapy following chemoresponse testing (65% adherence to test results), (2) assay adherent: modeled group assuming 100% adherence to assay results, and (3) empiric: modeled from market share data on most frequently utilized chemotherapy regimens. Cost estimates were based on commercial claims database reimbursements.

The most common chemotherapy regimens used were topotecan, doxorubicin, and carboplatin/paclitaxel. Mean chemotherapy costs for 6 cycles were $48,758 (empiric), $33,187 (assay assisted), and $23,986 (assay adherent). The cost savings related to the assay were associated with a shift from higher- to lower-cost chemotherapy regimens and lower use of supportive drugs such as hematopoiesis-stimulating agents.

Conclusion of the study was that assay-assisted chemotherapy for recurrent ovarian cancer may result in reduced costs compared to empiric therapy. What most medical oncologists do now (PMID: 20417480).

04-17-2014, 08:15 PM	#2
gdpawel Senior Member Join Date: Aug 2006 Location: Pennsylvania Posts: 1,080	Comparative Effectiveness Research in Cancer Medicine One good example of Comparative Effectiveness Research in cancer medicine was a Duke University cost savings study on the impact of a chemoresponse assay on treatment costs for recurrent ovarian cancer. They sought to estimate mean costs of chemotherapy treatment with or without use of a chemoresponse assay. They estimated mean costs for 3 groups: (1) assay assisted: 75 women who received oncologist's choice of chemotherapy following chemoresponse testing (65% adherence to test results), (2) assay adherent: modeled group assuming 100% adherence to assay results, and (3) empiric: modeled from market share data on most frequently utilized chemotherapy regimens. Cost estimates were based on commercial claims database reimbursements. The most common chemotherapy regimens used were topotecan, doxorubicin, and carboplatin/paclitaxel. Mean chemotherapy costs for 6 cycles were $48,758 (empiric), $33,187 (assay assisted), and $23,986 (assay adherent). The cost savings related to the assay were associated with a shift from higher- to lower-cost chemotherapy regimens and lower use of supportive drugs such as hematopoiesis-stimulating agents. Conclusion of the study was that assay-assisted chemotherapy for recurrent ovarian cancer may result in reduced costs compared to empiric therapy. What most medical oncologists do now (PMID: 20417480).