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Old 09-17-2012, 12:55 PM   #1
chrisy
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Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
Perjeta - leap of faith

Well, I am sitting here watching the last few drops of a Perjeta IV!

Then a loading dose (again) of herceptin...

The leap of faith is that it really is, as the clinic staff assured me and dr Rugo, authorized by my insurance! I have not received anything either way so I'm nervous, but I believe things will work out. But I will be there with those who sat there afraid to open their EOB for sure!

This was really good news since I can't receive chemo with the gaping surgical wound in my leg. I can get started with the Perjeta and herceptin and then we will add in taxotere when the wound heals. The combination of the two antibodies has some published data showing efficacy of the combo after herceptin resistance.

In the meantime, yesterday I got a contraption called a wound-vac which is basically a little vacuum that you wear and has a tube going into the wound dressing which sucks the fluid out and presumably speeds the healing process by drawing the good healing stuff to where it is supposed to go. In my case there is not a lot of drainage, so the thing makes a constant sound of someone sucking a straw to get the last bit of a chocolate shake! You know the sound

Wish me luck on the new combo, and that the insurance actually will come through!
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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