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Joan M · 03-13-2013, 05:58 PM

I have never taken TDM1 or tykerb, but I had a brain met. The met was treated with surgery and then 5 dosages of IMRT, or targeted radiation. It was a little too big (2.6 cm) and too deep for just one shot of stereotatic radiosurgery (that is, each tumor gets just one shot of radiation). I remember being very disappointed and needless to say, frightened about the surgery, as it seemed that several women on this board were able to have SRS.

Targeted radiation can be used even if you have several brain mets. Each met is individually targeted. There are a few types. One is Cyberknife, another is IMRT. If you decided to do brain radiation, ask your oncologist about using targeted therapy.

TDM1 has a good side effect profile, and tykerb crosses the blood brain barrier.

Good luck with your treatment!

Joan

03-13-2013, 05:58 PM	#2
Joan M Senior Member Join Date: Oct 2007 Posts: 1,851	Re: Tdm1/kadcyla and Tykerb I have never taken TDM1 or tykerb, but I had a brain met. The met was treated with surgery and then 5 dosages of IMRT, or targeted radiation. It was a little too big (2.6 cm) and too deep for just one shot of stereotatic radiosurgery (that is, each tumor gets just one shot of radiation). I remember being very disappointed and needless to say, frightened about the surgery, as it seemed that several women on this board were able to have SRS. Targeted radiation can be used even if you have several brain mets. Each met is individually targeted. There are a few types. One is Cyberknife, another is IMRT. If you decided to do brain radiation, ask your oncologist about using targeted therapy. TDM1 has a good side effect profile, and tykerb crosses the blood brain barrier. Good luck with your treatment! Joan __________________ Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!! Last edited by Joan M; 03-13-2013 at 06:01 PM..