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"The results showed that without the presence of PTHrP in the breast, even before the tumor developed, a reduction of 80 to 90 per cent in the growth of the tumor was observed," explains Dr. Kremer. "The removal of this hormone in the breast and breast tumors block not only the growth of the tumors but also its spread to different organs."
In order to bring this strategy one step closer to the patient, Dr. Kremer and his team developed a monoclonal antibody against PTHrP - a molecule that mimics the antibodies produced as part of the immune system's response to invaders, which is widely used in cancer treatment. Researchers were able to stop the growth of human breast tumors implanted in animal models and their metastatic spread, paving the way for clinical trials in the near future.
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