Low-dose naltrexone for disease prevention and quality of life
http://www.opioids.com/naltrexone/lowdosenaltrexone.pdf
Norman Brown a,*, Jaak Panksepp b
a Department of Humanities and Social Sciences, Embry-Riddle Aeronautical University, Daytona Beach, FL 32114, United States
b Department of VCAPP, College of Veterinary Medicine, Washington State University, P.O. Box 646520, Pullman, WA 99164-6520, United States
a r t i c l e i n f o
Article history:
Received 3 June 2008
Accepted 12 June 2008
s u m m a r y
The use of low-dose naltrexone (LDN) for the treatment and prophylaxis of various bodily disorders is
discussed. Accumulating evidence suggests that LDN can promote health supporting immune-modulation
which may reduce various oncogenic and inflammatory autoimmune processes. Since LDN can
upregulate endogenous opioid activity, it may also have a role in promoting stress resilience, exercise,
social bonding, and emotional well-being, as well as amelioration of psychiatric problems such a autism
and depression. It is proposed that LDN can be used effectively as a buffer for a large variety of bodily and
mental ailments through its ability to beneficially modulate both the immune system and the brain neurochemistries
that regulate positive affect.
2008 Published by Elsevier Ltd.