HER2 Support Group Forums - View Single Post - COX2 and BC a cumulative knowledge thread

R.B. · 11-05-2007, 06:24 PM

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells.
DÃ*az-Cruz ES, Shapiro CL, Brueggemeier RW.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.

"Thus, COX inhibitors decrease aromatase mRNA expression and enzymatic activity in human breast cancer cells in culture, suggesting that these agents may be useful in suppressing local estrogen biosynthesis in the treatment of hormone-dependent breast cancer."

11-05-2007, 06:24 PM	#8
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells. DÃ*az-Cruz ES, Shapiro CL, Brueggemeier RW. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA. "Thus, COX inhibitors decrease aromatase mRNA expression and enzymatic activity in human breast cancer cells in culture, suggesting that these agents may be useful in suppressing local estrogen biosynthesis in the treatment of hormone-dependent breast cancer."