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Lani · 01-11-2008, 11:10 AM

the cell lines used in these experiments were not her2 amplified or overexpressed

As it says in SOME cases of estrogen resistance growth factor expression is increased, but I am unsure whether you can correlate these experiments with
what would have happened had they tested with BT474 or SKBR 3 (her2+ breast cancer cell lines)where her2 amplification occurs.

Cell lines may or may not maintain the characteristics of the cancer as it behaved in a human body as well--some of these things have been kept in petri dishes for many years (perhaps decades) and mutations may have occured to adapt to the unusual enviroment!

01-11-2008, 11:10 AM	#2
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Robin P-- the cell lines used in these experiments were not her2 amplified or overexpressed As it says in SOME cases of estrogen resistance growth factor expression is increased, but I am unsure whether you can correlate these experiments with what would have happened had they tested with BT474 or SKBR 3 (her2+ breast cancer cell lines)where her2 amplification occurs. Cell lines may or may not maintain the characteristics of the cancer as it behaved in a human body as well--some of these things have been kept in petri dishes for many years (perhaps decades) and mutations may have occured to adapt to the unusual enviroment!