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Joan M · 02-23-2012, 06:40 PM

My heart goes out to you. Don't give up the ship ever!! There are many chemos that you have not yet tried, and also trials. Try to contact Roche about whether you can enter a T-DM1 trial. Ask them about Pertuzumab's approval in the EU. The CLEOPATRA trial was very successful, and the FDA is going to give the drug a quick review in June, rather than waiting the normal 10-12 months. Look at clinicaltrials.gov. I believe it also lists sites outside the U.S. where breast cancer trials in general are being offered. If you are able to come here, you have that option.

What treatment is your oncologist proposing? Are you able to get a second opinion if you wanted?

Many hugs, love,

Joan

02-23-2012, 06:40 PM	#13
Joan M Senior Member Join Date: Oct 2007 Posts: 1,851	Re: Bad Pet. I need you. My heart goes out to you. Don't give up the ship ever!! There are many chemos that you have not yet tried, and also trials. Try to contact Roche about whether you can enter a T-DM1 trial. Ask them about Pertuzumab's approval in the EU. The CLEOPATRA trial was very successful, and the FDA is going to give the drug a quick review in June, rather than waiting the normal 10-12 months. Look at clinicaltrials.gov. I believe it also lists sites outside the U.S. where breast cancer trials in general are being offered. If you are able to come here, you have that option. What treatment is your oncologist proposing? Are you able to get a second opinion if you wanted? Many hugs, love, Joan __________________ Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!