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Re: Secondary Angiosarcoma to the breast?
Yes, I first learned of this when an acquaintance was diagnosed with it. Since then I've known of 2 others. Two are alive at >5 years out and apparently okay, but one died quite quickly.
And it's not just limited to after lumpectomy -- lots of us got rads after mastectomy.
But the main thing is that it's REALLY rare. Here's a systematic review from 2012, which states: "After radiotherapy, the cumulative RIS incidence is 3.2 per 1,000 at 15 years (versus 2.3 per 1,000 for primary sarcoma in a population without radiotherapy)"
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3/01 ~ Age 49. Occult primary announced by large (6cm) axillary node, found by my husband.
4/01 ~ Bilateral mastectomies (LMRM, R elective simple) - 1.2cm IDC was found at pathology. 5 of 11 axillary nodes positive, largest = 6cm. Stage IIIA
ERPR 5%/1% (re-done later at Baylor, both negative at zero).
HER2neu positive by IHC and FISH (8.89).
Lymphovascular invasion, grade 3, 8/9 modified SBR.
TX: Control of arm of NSABP's B-31 adjuvant Herceptin trial (no Herceptin, inducing a severe case of Herceptin-envy): A/C x 4 and Taxol x 4 q3weeks, then rads. Raging infection of entire chest after small revision of mastectomy scar after completing tx (significance unknown). Arimidex for two years, stopped after second pathology opinion.
2017: Mild and manageable lymphedema and some cognitive issues.
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