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Old 05-07-2010, 11:54 AM   #7
Rich66
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Join Date: Feb 2008
Location: South East Wisconsin
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Re: Counterintuitive, estradiol as treatment

My this all gets complicated. I hadn't factored in Fulvestrant destroying the receptors that adding Estradiol woudl depend on. Although...if there is growth after Fulvestrant is stopped, there might be new estrogen receptors on the new cells.

"I was very nervous, especially when the doc did not want to do the two fdg-pet scan to get early indication of if it'd work"

Another interesting consideration. Especially since it can take months for endocrine therapy to show "shrinkage" on a CT. But..I think I saw somewhere that endocrine therapy can induce an initial flare:

Video clip from makers of Faslodex on hormonal aspects of BC:
http://www.hormonalaspectsofbc.com/p...211/index.html

Of note is that host says it can take 3 months before effectiveness is shown in hormonal therapy. Tumor can initially enlarge and Markers can rise even when eventually effective.


More on PET/CT as check:http://her2support.org/vbulletin/showthread.php?t=38950
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