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Re: High Dose Tykerb Experiment - wish me luck!
Courtney, good luck. I tried a mini experiment too (with my onc's approval) after reading an an article posted by Rich or GDPawel. I think it was referred to as "pulse" doses or something. I am sensitive to Tykerb so I only went up to 3000mg a day for three days around the time of my weekly Abraxane. Think I only tried it for 2 cycles bc that was all I had of the drug at the time. I can't be sure of the timing of the onset of my response but I did only start showing good response when Tykerb was added to the Abraxane/Herceptin mix. You could hardly say I was rigorous in my methodology! I am now on a more conventional daily 750mg and still responding. Fingers crossed.
Hope it works to keep your pesky mets at bay.
Trish
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5/2004 (R) 30mm bre gr3 infiltrating ductal ca 16/18nodes er (2+) pr (3+) HER2 (3+)
6/2004 6 cycles(FEC), Oct 40 rads, Tamoxifen
5/2006 oopherectomy, Arimedex
12/2006 liver mets largest 9cm
1/2007 Herceptin,
3/2007 Taxol + Herc
1/2008 Herc alone
4/2008 Multiple bone mets,Zometa
7/2008 Herc + Gemcitabine
8/2008 Herc+Navelbine/vinoralbine
10/2008 Herc+Carboplatin+Taxol
12/2008 Tykerb+Xeloda
2/2010 Herceptin + trial drug
5/2010 Herceptin+Tykerb
8/2010 Tykerb+Abraxane
9/2010 Abraxane
12/2010 Abraxane+Tyk+Herc
4/2011 Tyk+Herc+Femara
6/2011 Liver and bone mets prog.Abraxane continue Herceptin,Tykerb,Femara and Zometa
8/2011 Probable liver progression and increased neuropathy. Xeloda with Tyk+Herc. Zometa 6 weekly.
9/2011 Liver progression,TM +++. Cyclophosphamide and Methotrexate metro Herc Zometa
10/2011 liver mets prog.Herc, 3 Tykerb +2mg decodron daily,Zometa
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