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Old 11-15-2006, 08:21 AM   #8
Becky
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Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
Dear Astrid


Tamoxifen does not suppress estrogen manufacture by the ovaries, adrenals or adipose tissue. Tamoxifen covers the estrogen receptor on the surface of breast/breast cancer cells so that estrogen cannot bind there. If estrogen does bind, it causes the excitation of the cell that leads to proliferation/reproduction.

This is why your estrogen levels are normal for a premenopausal/perimenopausal woman (because there is no ovarian suppression involved with Tamoxifen alone).

Kind regards

Becky
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