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Re: almost 14 years NED breast cancer and apparently it's back in my lungs
Hi all;
Got some results from my genetic testing. I was tested for 17 genes and remain normal for all but still BRCA1 VUS. She is hoping for more information on this from the testing of my tumours....breast mets and ovarian....but I don't really understand why. I am normal for ATM, BRCA2, BRIP1, CDH1, CKEK2, EPCAM, MLS1, MSH2, MSH6, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, and TP53. I am also negative for Lynch syndrome. Testing was done at Invitae Laboratory in the US.
Also, my oncologist said today that the Ontario Octane program which I have become part of is testing all of the mutations of my tumours and will continuously run these by all drugs. As new ones enter clinical trials they will tell my oncologist. If/when Ibrance/Letrozole stops working for me they will then decide what offers the best next treatment for me.
The oncologist told me today that they could not have hoped for better results than I am having right now....no new tumours, no indication of any issues with the ovarian cancer and existing tumours are shrinking. Plus my side effects still offer me a good QOF.
Even though I had seen the scan results which I posted here I'm feeling pretty happy tonight.
As I keep posting, apparently in December a paper will be presented about the use of Ibrance/Letrozole on hormone positive Her2+ as well as Her2- MBC.
My best to you all,
Cathy
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Cathy
Diagnosed Oct. 2004 3 cm ductal, lumpectomy Nov. 2004
Diagnosed Jan. 2005 tumor in supraclavicular node
Stage 3c, Grade 3, ER/PR+, Her2++
4 AC, 4 Taxol, Radiation, Arimidex, Actonel
Herceptin for 9 months until Muga dropped and heart enlarged
Restarting herceptin weekly after 4 months off
Stopped herceptin after four weekly treatments....score dropped to 41
Finished 6 years Arimidex
May 2015 diagnosed with ovarian cancer
Stage 1C
started 6 treatments of carboplatin/taxol
Genetic testing show BRCA1 VUS
Nice! My hair came back really curly. Hope it lasts lol. Well it didn't but I liked it so I'm now a perm lady
29 March 2018 Lung biopsy following chest CT showing tumours in pleura of left lung, waiting for results to the question bc or ovarian
April 20, 2018 BC mets confirmed, ER/PR+ now Her2-
Questions about the possibility of ovarian spread and mets to bones so will be tested and monitored for these.
To begin new drug Palbociclib (Ibrance) along with Letrozole May, 2018.
Genetic testing of ovarian tumour and this new lung met will take months.
To see geneticist to be retested for BRCA this week....still BRCA VUS
CA125 has declined from 359 to 12 as of Aug.23/18
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