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Re: Sabcs 2012
packing up and leaving sabcs--quick answer
fabulous lecture by Dr. Yosef Yarden explained that her2 amplification is found more often in DCIS than IDC, but frequently there is adjacent her2+ DCIS with her2+ IDC as there is a "two hit" development process for her2+ breast cancer, where in her2 amplification has the effect of causing cells to accumulate within the duct (there is no canalization to make an empty duct as there is in normal development) and then a second hit affects p53 which indirectly affects the normal cell cycle check which prevents uncontrolled cell division (the "brake")
The lecture should be available online in January and I recommend everyone to listen to it.
More later
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