HER2 Support Group Forums - View Single Post - any tumor tests to predict which chemos work better?

gdpawel · 02-21-2012, 05:09 PM

I'd just wish they would use "fresh" live cells instead of formalin-fixed paraffin-embedded tissue. These proliferating populations of cells are biologically distinct in their behavior from "fresh" live cells that comprise human tumors.

When it comes to "drug selection," investigators can only measure those analytes (substance or chemical constituent) in paraffin wax that they know to measure. If you are not aware of and capable of measuring a biologically relevant event, you cannot seek to detect it.

The NCI spent years trying to find patterns which correlated using NCI's various established cell-lines. They thought they had something, but when they started to apply them to fresh tumor specimens, none of the results in the cell-lines was applicable to the fresh tumors.

02-21-2012, 05:09 PM	#36
gdpawel Senior Member Join Date: Aug 2006 Location: Pennsylvania Posts: 1,080	Re: any tumor tests to predict which chemos work better? I'd just wish they would use "fresh" live cells instead of formalin-fixed paraffin-embedded tissue. These proliferating populations of cells are biologically distinct in their behavior from "fresh" live cells that comprise human tumors. When it comes to "drug selection," investigators can only measure those analytes (substance or chemical constituent) in paraffin wax that they know to measure. If you are not aware of and capable of measuring a biologically relevant event, you cannot seek to detect it. The NCI spent years trying to find patterns which correlated using NCI's various established cell-lines. They thought they had something, but when they started to apply them to fresh tumor specimens, none of the results in the cell-lines was applicable to the fresh tumors.