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Kmswilson · 02-26-2012, 03:20 PM

i started out with an 11x12 cm liver tumor, and several 6 cm and 3 and 4 cm along with countless small tumors. Basically, my liver is full of it. That was a 13 months ago. I've been dancing with it for the last year on several chemos and herceptin, and now I'm down to a few 3 and 4 cm tumors along with countless small ones, though they have reduced some in number, there are still too many to count. I've had progression and regression, back and forth. I figure I'm going to dance with it as long as I can, and if I can keep dancing or even get some stability, I'll take it until they find our cure! That being said, since I recently had brain mets and finished WBR, I'm now waiting to start on Tykerb and Xeloda to see how that combo does for me. Tykerb since I need something for the blood brain barrier, and my onc said since I'd shown some resistance to Herceptin, maybe the Tykerb will shock it a little. I'm a little worried since Ive been off chemo for 6 weeks now and have a week and a half until I get started again. And a little worried about the toxicity warnings about liver for Tykerb, but I'm trusting that the right combo is out there for me, I just have to find it and trust that all will be well. I hope the same for you. This can be so scary and disheartening. Hang in there.

02-26-2012, 03:20 PM	#8
Kmswilson Senior Member Join Date: Jan 2011 Posts: 40	Re: Big Liver Met & Herceptin Resistance i started out with an 11x12 cm liver tumor, and several 6 cm and 3 and 4 cm along with countless small tumors. Basically, my liver is full of it. That was a 13 months ago. I've been dancing with it for the last year on several chemos and herceptin, and now I'm down to a few 3 and 4 cm tumors along with countless small ones, though they have reduced some in number, there are still too many to count. I've had progression and regression, back and forth. I figure I'm going to dance with it as long as I can, and if I can keep dancing or even get some stability, I'll take it until they find our cure! That being said, since I recently had brain mets and finished WBR, I'm now waiting to start on Tykerb and Xeloda to see how that combo does for me. Tykerb since I need something for the blood brain barrier, and my onc said since I'd shown some resistance to Herceptin, maybe the Tykerb will shock it a little. I'm a little worried since Ive been off chemo for 6 weeks now and have a week and a half until I get started again. And a little worried about the toxicity warnings about liver for Tykerb, but I'm trusting that the right combo is out there for me, I just have to find it and trust that all will be well. I hope the same for you. This can be so scary and disheartening. Hang in there. __________________ Krissi 12/27/10 - IDC, rt breast (approx. 15 cm), lymph nodes, age 36. 1/7/11 - stage 4 IDC, extensive liver mets, Bone mets (spine, sacrum, rib, sternum, upper arm), ER-/PR-, HER2+++; 1/12/11 - port, 1/17/11- startweekly Taxol/Herceptin, monthly Zometa 3/8/11- decrease in all tumors, bones healing. 3/11- 3 wks on/1 off Taxol/Herceptin, +Zometa 6/6/11 - decrease in all tumors, healing bones, 2-4 new liver lesions. 3 wks on/1 wk off Taxol/Carbo/Herceptin, +Zometa 7/29/11 - liver progression, others stable; 8/11-drop taxol/carbo, start Navelbine 12/11 - liver progression; begin AC, drop Herceptin; 1/12 - liver enzymes normal, 2/6 results show regression in liver, stable others, but 9 tiny brain mets (largest 7 mm). Begin 13 WBRs 2/6; 2/29-start Tykerb, 3/7, start Xeloda 5/2012- liver progression and regression, liver biopsy confirms HER2+++. drop Xeloda, start Herceptin, Tykerb, Zometa. 5/2012- brain MRI shows all lesions gone except 1, 2mm shrinking!