HER2 Support Group Forums - View Single Post - Update - progression confirmed; the last shoe drops

Becky · 06-16-2011, 01:47 PM

Chrisy

Perhaps the met turned hormone positive and is screaming out for tamoxifen or something - just a thought.

On what chemo drug that is linked to TMD1 - it may have to do what they can chemically link to Herceptin without destroying Herceptin's properties (so that it rushes to Her2 receptors). It may also be catalyst dependent (to keep the chemical reaction's temperature low also to protect the Herceptin). I am sure the biochemists are thinking but the bonds they would have to use to join the 2 molecules would have to work out with each other and the chemical reaction has to be right to maintain the properties of each component (Herceptin to the Her2 receptor and that the chemo part also acts as chemo).

06-16-2011, 01:47 PM	#37
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Update - progression confirmed; the last shoe drops Chrisy Perhaps the met turned hormone positive and is screaming out for tamoxifen or something - just a thought. On what chemo drug that is linked to TMD1 - it may have to do what they can chemically link to Herceptin without destroying Herceptin's properties (so that it rushes to Her2 receptors). It may also be catalyst dependent (to keep the chemical reaction's temperature low also to protect the Herceptin). I am sure the biochemists are thinking but the bonds they would have to use to join the 2 molecules would have to work out with each other and the chemical reaction has to be right to maintain the properties of each component (Herceptin to the Her2 receptor and that the chemo part also acts as chemo). __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"