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Darlene Denise · 10-29-2010, 06:02 PM

Kim: I love the Cyberknife, but not a fan of it's use in the liver. Lesion total volume has to be less than 6 cm. Primary reason, is the liver does not regenerate from radiation. I have consulted in regard to my liver. I would think it could be a good option for your other met though.

I have also consulted for RFA, Nanoknife, Cryoablation and surgery. Unfortunately, my lesions are to close to the portal vein and bile ducts to use any focalized treatment. My consults were just a few months before starting TDM!.

From my inquiries and reading, I favor either surgery or Cyroablation. There is recent data that indicates using Cyroablation (freezing) induces an immune response by the body against bc. I also like that as the ice ball forms in the lesion, it is very easily seen on real time CT to get all of the lesion and spare healthy liver tissue.

If I were in your situation, I would certainly consult for the focalized or surgical options.

By the way, PARP is for triple negatives. There is a vaccine trial for advanced breast cancer at University of PA and Hopkins. Also look into PKI3, which is an inhibitor of another pathway in Her 2 +, Sarah Cannon, Dana Farber currently have some in study. May be some in your area.

Sorry for this unexpected progression. Keep us up to date.

Stay strong....Darlene

10-29-2010, 06:02 PM	#10
Darlene Denise Senior Member Join Date: Aug 2008 Location: Virginia Beach, Virginia Posts: 145	Re: long run with TDM1 is over Kim: I love the Cyberknife, but not a fan of it's use in the liver. Lesion total volume has to be less than 6 cm. Primary reason, is the liver does not regenerate from radiation. I have consulted in regard to my liver. I would think it could be a good option for your other met though. I have also consulted for RFA, Nanoknife, Cryoablation and surgery. Unfortunately, my lesions are to close to the portal vein and bile ducts to use any focalized treatment. My consults were just a few months before starting TDM!. From my inquiries and reading, I favor either surgery or Cyroablation. There is recent data that indicates using Cyroablation (freezing) induces an immune response by the body against bc. I also like that as the ice ball forms in the lesion, it is very easily seen on real time CT to get all of the lesion and spare healthy liver tissue. If I were in your situation, I would certainly consult for the focalized or surgical options. By the way, PARP is for triple negatives. There is a vaccine trial for advanced breast cancer at University of PA and Hopkins. Also look into PKI3, which is an inhibitor of another pathway in Her 2 +, Sarah Cannon, Dana Farber currently have some in study. May be some in your area. Sorry for this unexpected progression. Keep us up to date. Stay strong....Darlene __________________ 12/14/07 IDC ER- PR- HER2+++ LIVER METS AT DX CONFIRMED BY LIVER BIOPSY 01/14/08 2 AC TREATMENTS-NOT WORKING 02/04/08 13 TAXOL, CARBO, HERCEPTIN TREATMENT-EXCELLENT RESULTS! 05/12/08 HERCEPTIN EVERY 3 WKS 08/22/08 BRAIN METS! 8 <5MM 09/17/08 CYBERKNIFED BRAIN METS 10/20/08 BRAIN METS SHRINKING 12/29/08 BRAIN SCAN SHOWS 1 LESION GONE, 7 SHRINKING & STABLE, 1MM ? SPOT 01/16/09 LIVER REOCUR-XELODA/HERCEPTIN 03/02/09 BRAIN SCAN 2 LESIONS GONE, 5 STABLE, 1MM ? SPOT STILL A ? 3/27/09 REGRESSION OF 2 LIVER LESIONS XELODA & HERCEPTIN 06/08/09 STUPID BRAIN HAS 3 LESIONS 06/29/09 CYBERKNIFE 07/01/09 LIVER REGRESSION NO NEW METS 07/07/09 TYKERB XELODA HERCEPTIN 11/11/09 GEMZAR/HERCEPTIN FOR LIVER PROGRESSION 03/22/10 BRAIN MRI GOOD-3 SMALL NECROSIS LEFT FROM ORIG 11!! 03/26/10 CHANGE TO NAVELBINE/HERCEPTIN 3 LIVER LESIONS PROGRESSING IN SIZE 05/21/10 NAVELBINE/HERCEPTIN WORKING! 07/19/10 GOOD BRAIN MRI 08/20/10 LIVER PROGRESSION 09/08/10 TDM1 - NASHVILLE TN 01/10/11 LIVER RESPONDING TO TDM1