HER2 Support Group Forums - View Single Post - Pattern of recurrence of early bc differs by intrinsic subtype & proliferation index

Laurel · 10-24-2013, 06:48 PM

Smart People than I,

I am a bit confused by this study and think I must be reading it wrongly. Please, if anyone can, help me to wrap my brain around this. On page #14 in table #9 I see that the hazard ratio for recurrence in Luminal Her2 is actually declining annually through years 5-7. It appears that Her2 Enriched does spike around year 5, however. Isn't Luminal Her2 that which is Er or Pr (or both) positive and Her2 positive (Er/pr+, Her2 +) while Her2 Enriched is Her2 positive, but hormonally negative (Er/Pr-, Her2 +)? I must be reading that table wrongly because according to my interpretation Luminal Her2s would not require a booster, but Her2 Enriched would qualify.

Anyone?

10-24-2013, 06:48 PM	#17
Laurel Senior Member Join Date: May 2008 Location: Hershey, PA. Live The Sweet Life! Posts: 2,005	Re: Pattern of recurrence of early bc differs by intrinsic subtype & proliferation in Smart People than I, I am a bit confused by this study and think I must be reading it wrongly. Please, if anyone can, help me to wrap my brain around this. On page #14 in table #9 I see that the hazard ratio for recurrence in Luminal Her2 is actually declining annually through years 5-7. It appears that Her2 Enriched does spike around year 5, however. Isn't Luminal Her2 that which is Er or Pr (or both) positive and Her2 positive (Er/pr+, Her2 +) while Her2 Enriched is Her2 positive, but hormonally negative (Er/Pr-, Her2 +)? I must be reading that table wrongly because according to my interpretation Luminal Her2s would not require a booster, but Her2 Enriched would qualify. Anyone? __________________ Smile On! Laurel Dx'd w/multifocal DCIS/IDS 3/08 7mm invasive component Partial mast. 5/08 Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH 0/5 nodes 4 AC, 4 TH finished 9/08 Herceptin every 3 weeks. Finished 7/09 Tamoxifen 10/08. Switched to Femara 8/09 Bilat SPM w/reconstruction 10/08 Clinical Trial w/Clondronate 12/08 Stopped Clondronate--too hard on my gizzard! Switched back to Tamoxifen due to tendon pain from Femara 15 Years NED I think I just might hang around awhile....