[Lani]

Estrogen DOES cross the blood brain barrier and just because your ovaries were removed doesn't mean you are not making estrogen to feed your tumor.

Even with your ovary removed, your body makes estrogen (from testosterone) in your liver, muscles and fat AND most importantly locally around your breast (for the primary) and even perhaps around your mets. It seems the breast cancer tumor cells and their surrounding stroma cells may have a thing going where they can cause testosterone locally to turn to estrogen and AROMATASE is only ONE OF THREE ENZYMES that can help them do it. Even AIs only block one of the three enzymes.

Tamoxifen may have more actions than just sitting on the estrogen receptor and blocking it

So removing your ovaries does not prevent Estrogen from fueling growth of breast cancer.

If you don't think estrogen crosses the blood-brain barrier, then you must think men and women think alike!

Just joking...