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Old 09-14-2013, 03:06 PM   #13
Mtngrl
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Join Date: May 2011
Location: Denver, CO
Posts: 1,427
Re: The Pink-tober Madness begins!

Let me just say, for the record, that it's not at all clear that "early detection saves lives." If they could really tell which cancers were dangerous and which were not, that might be true. But by shifting the focus from (a) prevention (and I mean efforts to find out what's causing it and eliminate the causes--such as the soup of industrial pollutants that we all soak up every day) and (b) cure to "Let's find out you have it and do our standard 'slash, burn and poison' on everyone and, oh, by the way, we'll make billions of dollars on routine screening" I am not going to advocate everyone getting mammograms every year from age 40 on. Lots of false positives. Lots of false negatives. Lots of money to be made scaring people into thinking they have a higher risk of getting this disease than they really do (and then duping them into thinking early detection = cure.) The fact is, about 30% of people diagnosed and treated at a lower stage progress to Stage IV, and about 10% are Stage IV at diagnosis. Those are not particularly good survival statistics. I do not believe you can consider any breast cancer curable. We need to learn what causes metastasis and how to stop it. Then we can all go "racing for the cure" to make sure everyone gets that--a vaccine or a pill or whatever.

The gold standard in cancer is PREVENTION. Lung cancer rates have plummeted along with rates of smoking. Stomach cancer is almost a thing of the past now that we have refrigeration and antibiotics. Cervical cancer in women and throat cancer in men is now preventable with an HPV vaccine. That's what we need.

We know people--dear, beloved, sorely missed sisters on this board--who were diagnosed and treated at Stage 0 and died anyway. We'll never know how many were diagnosed "early" and went through all the trauma of treatment who would not have died if it had been found later, when they were symptomatic. A short time back an "accidental" pairing of matched populations in Europe showed NO difference in overall survival between starting routine screening early and starting it later. OTOH, it might make all the difference for an individual. At this time, there is no way to tell.

I have a friend who found her own enlarged axillary lymph node ONE MONTH after a "clear" mammogram. I have another friend who has a similar story. They are both Stage IV. I was maybe a little behind in my mammo schedule (due to insurance/budget concerns) but not all that far behind, and my tumor would have been Stage II if not for those pesky mets they found at diagnosis. So spare me the "early detection saves lives" mantra. You can't prove it.
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Amy
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4/19/11 Diagnosed invasive ductal carcinoma in left breast; 2.3 cm tumor, 1 axillary lymph node, weakly ER+, HER2+++
4/29/11 CT scan shows suspicious lesions on liver and lungs
5/17/11 liver biopsy
5/24/11 liver met confirmed--Stage IV at diagnosis
5/27/11 Begin weekly Taxol & Herceptin for 3 months (standard of care at the time of my DX)
7/18/11 Switch to weekly Abraxane & Herceptin due to Taxol allergy
8/29/11 CT scan shows no new lesions & old lesions shrinking
9/27/11 Finish Abraxane. Start Herceptin every 3 weeks. Begin taking Arimidex
10/17/11--Brain MRI--No Brain mets
12/5/11 PET scan--Almost NED
5/15/12 PET scan shows progression-breast/chest/spine (one vertebra)
5/22/12 Stop taking Arimidex; stay on Herceptin
6/11/12 Started Tykerb and Herceptin on clinical trial (w/no chemo)
9/24/12 CT scan--No new mets. Everything stable.
3/11/13 CT Scan--two small new possible mets and odd looking area in left lung getting larger.
4/2/13--Biopsy of suspicious area in lower left lung. Mets to lung confirmed.
4/30/13 Begin Kadcyla/TDM-1
8/16/13 PET scan "mixed," with some areas of increased uptake, but also some definite improvement, so I'll stay on TDM-1/Kadcyla.
11/11/13 Finally get hormone receptor results from lung biopsy of 4/2/13. My cancer is no longer ER positive.
11/13/13 PET scan mixed results again. We're calling it "stable." Problems breathing on exertion.
2/18/14 PET scan shows a new lesion and newly active lymph node in chest, other progression. Bye bye TDM-1.
2/28/14 Begin Herceptin/Perjeta every 3 weeks.
6/8/14 PET "mixed," with no new lesions, and everything but lower lungs improving. My breathing is better.
8/18/14 PET "mixed" again. Upper lungs & one spine met stable, lower lungs less FDG avid, original tumor more avid, one lymph node in mediastinum more avid.
9/1/14 Begin taking Xeloda one week on, one week off. Will also stay on Herceptin and Perjeta every three weeks.
12/11/14 PET Scan--no new lesions, and everything looks better than it did.
3/20/15 PET Scan--no new lesions, but lower lung lesions larger and a bit more avid.
4/13/15 Increasing Xeloda dose to 10 days on, one week off.
7/1/15 Scan "mixed" again, but suggests continuing progression. Stop Xeloda. Substitute Abraxane every 3 weeks starting 7/13.
10/28/15 PET scan shows dramatic improvement everywhere. All lesions except lower lungs have resolved; lower lungs noticeably improved.
12/18/15 Last Abraxane. Continue on Herceptin and Perjeta alone beginning 1/8/16.
1/27/16 PET scan shows cancer is stable.
5/11/16 PET scan shows uptake in some areas that were resolved on the last two scans.
6/3/16 Begin Kadcyla and Tykerb combination
6/5 - 6/23 Horrible diarrhea from K&T together. Got pneumonia.
7/15/16 Begin Kadcyla only every 3 weeks.
9/6/16 Begin radiation therapy on right lung lesion that caused the pneumonia.
10/3/16 Last of 12 radiation treatments to right lung.
11/4/16 Huffing and puffing, low O2, high heart rate, on tiniest bit of exertion. Diagnosed as radiation pneumonitis. Treated with Prednisone.
11/11/16 PET scan shows significant improvement to radiated part of right lung BUT a bunch of new lung lesions, and the bone met is getting worse.
11/22/16 Begin Eribulin and Herceptin. H every 3 weeks. E two weeks on, one week off.
3/6/17 Scan shows progression in lungs. Bone met a little better.
3/23/17 Lung biopsy. Tumor sampled is ER-, PR+ (5%), HER2+++. Getting Herceptin and Perjeta as a maintenance treatment.
5/31/17 Port placement
6/1/17 Start Navelbine & Tykerb
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