[phil]

my wife has been on it 3 yrs. s/e were not as bad as yours , for many they get better as you go along. I would encourage sticking w/ full dose , if u can stand it , till you get scans. see if you're getting response. my wife did have to reduce after 7 doses to 3.0 , and still got good results , eventually ned by one yr. of tx. maybe you can flex schedule a bit, to every 4 weeks. that's what we're heading for, altho, on the other hand , every 4 weeks for my wife does give her a little worse s/e 's for her , maybe body loses a little resistance to s/e when schedule changes ? . its tricky. her s/e are low plats , causing a black eye /bloody noses, red spots on skin, fatigue, some depression days 7-10 that passes. liver irritation that drops if drug is delayed. we don't know the drug that well yet - its the first widely used conjugate , genetic/chemo attached . Good Luck.