This was posted on bc mets by Musa Mayer
Since you ask....I did look up the medical
literature on DCA, and find that it's never been
tested in cancer. Only a small fraction of
substances that kill cancer cells in the lab turn
out to actually work and be safe, so until it is
tested in humans for this use, there's no way of
telling if it will work or not. It's a promising
first step, but it's only that.
One place I go to look to get a sense of new
breast cancer treatments in development that have
reached clinical trials testing is the website
for Pharmaceutical Research and Manufacturers of America (PhRMA)
the professional organization for the
pharmaceutica. and biotech industry.
http://www.phrma.org/
Below is a list of new drugs under development
for breast cancer, phases I, II and III from this
website. It is probably not complete or
up-to-date, but it will give you a sense of just
how much work is being done to find new
treatments. Some of these are very promising, in
late stage development, while others haven't
panned out, at least not yet. Others have been
approved for other cancers, and are being tested
in breast cancer. If past experience is any
predicter, over 90% will never make to market. But there will be some.
If you want to take a look at any of these drugs
under development, Google their names + "breast
cancer." This will usually take you to clinical
trials listings, abstracts in PubMed.gov
(scientific literature database), or to a company website.
Musa
2-Methoxyestradiol - EntreMed
ABT 751
AE37 cancer vaccine - Antigen Express
Afimoxifene
AMG 706
Amonafide
Amonafide malate - Xanthus Pharmaceuticals
Annamycin
Anti-MUC1 monoclonal antibody AR 20.5
BrevaRexMAB- ViRexx
Anti-PEM monoclonal antibody
Antineoplaston A10 - oral
Antineoplaston AS2 1 - oral
AP 23573
Arsenic trioxide
Arzoxifene
Atamestane
Axitinib
Bevacizumab - Avastin
Bexarotene oral
Biricodar
Incel™ Vertex Pharmaceuticals
Bleomycin-electrical pulse delivery
BMS 184476
Breast cancer vaccine HER-2/neu - GlaxoSmithKline
BZL 101
C 1311- Symadex™ Xanthus Pharmaceuticals
Cancer vaccine - Genzyme
Cancer vaccine E75 - Apthera
Cancer vaccine MUC - Memorial Sloan-Kettering Cancer Center
Cancer vaccine Theratope - Biomira
Canertinib
Canfosfamide
TELCYTA™ Telik
Combretastatin A4
Doxorubicin liposomal - ALZA
Doxorubicin liposomal - Elan
Lipodox® Pfizer
DTS 301
E 7389
Enzastaurin
Erlotinib
Exisulind
Formestane - Medical Discoveries
Gefitinib
Glufosfamide
GTI 2040
HER2-antigen specific cancer immunotherapeutic
HKI 272
Imexon - AmpliMed
Indisulan
INGN 201
ADVEXIN® Introgen Therapeutics Breast cancer
INGN 225
Interleukin-4(38-37)-PE38KDEL
Ipilimumab
Irofulven
Ispinesib
Ixabepilone
KOS 862
Labetuzumab
Lapatinib
Tykerb™ GlaxoSmithKline
Lapuleucel-T
Neuvenge™ Dendreon Corporation Breast cancer
Larotaxel
Liposome encapsulated doxorubicin
Liposome encapsulated paclitaxel
Lonafarnib
Losoxantrone
LTSDEL
Thermodox™ Celsion Corporation
Mammastatin replacement therapy
MDX H210
Methylenetetrahydrofolic acid
Milataxel
Mitoxantrone
MKC 1
Monoclonal antibody CC49
Monoclonal antibody HMFG1
MPI 5010
NBI 42902
NSC 655649
Oblimersen
Octreotide
OCX 0191
OPT 22
Paclitaxel - IVAX
Paxoral™ IVAX Corporation
Paclitaxel - Sonus Pharmaceuticals
Tocosol® paclitaxel Sonus Pharmaceuticals
Pelitrexol
Pemetrexed
Alimta® Eli Lilly Breast cancer USA II
Perifosine
Perillyl alcohol
PX 1041
R 440
Reximmune-C
Reximmune-C™ Epeius Biotechnologies
Rhizoxin
Rubitecan
Satraplatin
SR 16234
Sunitinib
Tacedinaline
Tanespimycin
Tariquidar
Temsirolimus
Tesmilifene
Testosterone propionate
Synerone® sanofi-aventis
Tetrathiomolybdate
Thalidomide
Tipifarnib
Zarnestra™ Johnson & Johnson Pharmaceutical Research & Development LLC
Topotecan
Trabectedin
Trastuzumab-DM1 immunoconjugate
Tretinoin
Trilostane
Trimetrexate
Vandetanib
WX UK1
Yttrium 90 labelled edotreotide
ZK epothilone