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rhondalea · 02-27-2012, 06:51 AM

I haven't taken AIs, but I have reason to believe that I may not tolerate them (or tamoxifen, which I'm supposed to start tomorrow) very well based on direct-to-consumer genetic profiling. Our genes determine how we metabolize certain drugs.

Here's a list of the known Cytochrome P450 Drug Interactions:

http://www.ildcare.eu/Downloads/arts...teractions.pdf

And here's a link to a power point presentation that explains how our genes affect drug metabolism.

http://www.genemedrx.com/explainreport.ppt

I am just learning about all this, and it's tough going because I don't have the scientific background to understand it easily, but you might want to might want to find out if there's anything else you can take (or stop taking, because certain supplements can act as inhibitors and inducers) to improve your ability to tolerate at least one of the AIs.

02-27-2012, 06:51 AM	#2
rhondalea Senior Member Join Date: Jun 2011 Location: Somerset, NJ Posts: 487	Re: Is there anyone who could not take AI's? I haven't taken AIs, but I have reason to believe that I may not tolerate them (or tamoxifen, which I'm supposed to start tomorrow) very well based on direct-to-consumer genetic profiling. Our genes determine how we metabolize certain drugs. Here's a list of the known Cytochrome P450 Drug Interactions: http://www.ildcare.eu/Downloads/arts...teractions.pdf And here's a link to a power point presentation that explains how our genes affect drug metabolism. http://www.genemedrx.com/explainreport.ppt I am just learning about all this, and it's tough going because I don't have the scientific background to understand it easily, but you might want to might want to find out if there's anything else you can take (or stop taking, because certain supplements can act as inhibitors and inducers) to improve your ability to tolerate at least one of the AIs. __________________ 2/6/09 Core needle biopsy: negative; Mammos through 2010: no change 3/30/11 Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much 4/14/11 Core needle biopsy: negative for cancer 5/18/11 Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5 6/15/11 BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3 7/14/11 CT/Bone scans NED; MUGA 66% 7/19/11 Biweekly dd AC w/Neulasta; done 8/30/11 9/13/11 Transfusion (Hemoglobin 8.6); MUGA 64% 9/20/11 Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012 12/27/11 Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy! 2/29/12 Start Tamoxifen 20 mg/day; continue until 2/28/17 5/16/12 Start five-years Metformin trial 6/19/12 MUGA 61% 8/21/12 Brain MRI NED (head still hurts, brain still fogged) 9/4/12 Herceptin done! 9/6/12 Port out! 7/11/13 Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13; back to 5mg 12/2013 5/2014 Add Namenda 7mg 9/2014 Stop Aricept and Namenda; Neuropsychological evaluation 10/24/14 Start cognitive rehabilitation therapy