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Old 11-29-2014, 06:39 PM   #13
rhondalea
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Join Date: Jun 2011
Location: Somerset, NJ
Posts: 485
Re: No Travel Required - KRAS-Variant Mutation and Breast Cancer

To the extent that I'm a customer of 23andMe, I have a personal interest in the company. If you asked other 23andMe'ers, you might find that many of them feel the same. I don't own stock, though. I'm simply fascinated by the promise of genetics for personalized medicine and what it can tell us about ourselves, and I've done my best to learn as much as I can about it. I signed up for the PGP so I could contribute to the science. I purchased 23andMe because I wanted some instant gratification with respect to my own genes. I had family members tested so I could work on the family tree as a gift to my grandson, because I realized how much of our history had been lost when my grandmother died.

Most of 23andMe's researchers have doctorates from the institutions you mentioned or similar. This is the scientific advisory board:
https://www.23andme.com/about/advisors/

and this is research team:
https://www.23andme.com/about/researchteam/

As I mentioned, I don't think 23andMe is appropriate for those who are hoping to choose between various cancer treatments, because for that you need to have the tumor itself tested.

I hope Dr. Weidhaas is able to provide you with the information you seek, but 23andMe does test for the KRAS variant (rs61764370). SNPedia has an entry with links to the various articles in PubMed about this SNP.
http://www.snpedia.com/index.php/Rs61764370
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2/6/09 Core needle biopsy: negative; Mammos through 2010: no change
3/30/11 Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much
4/14/11 Core needle biopsy: negative for cancer
5/18/11 Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5
6/15/11 BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3
7/14/11 CT/Bone scans NED; MUGA 66%
7/19/11 Biweekly dd AC w/Neulasta; done 8/30/11
9/13/11 Transfusion (Hemoglobin 8.6); MUGA 64%
9/20/11 Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012
12/27/11 Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy!
2/29/12 Start Tamoxifen 20 mg/day; continue until 2/28/17
5/16/12 Start five-years Metformin trial
6/19/12 MUGA 61%
8/21/12 Brain MRI NED (head still hurts, brain still fogged)
9/4/12 Herceptin done!
9/6/12 Port out!
7/11/13 Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13; back to 5mg 12/2013
5/2014 Add Namenda 7mg
9/2014 Stop Aricept and Namenda; Neuropsychological evaluation
10/24/14 Start cognitive rehabilitation therapy
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