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Interesting conference starts in Melbourne this afternoon, looking at controversies in breast cancer. The medical world so often presents itself as monolithic and beyond challenge, so this should be a welcome change of pace!

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Diagnosed 2004: Lumpectomy - 2 tumours, both grade 1 infiltrating duct carcinoma, about 12mm. ER+,
C-erbB-2 status 3+.
Clear margins, no nodal involvement.
Radiotherapy, i year Tamoxifen, 4 years Arimidex.
Rediagnosed 2012: Multiple bone metastases.
3/12: began on Marianne trial - T-DM1 + Pertuzamab/Placebo.
5/12:Unexpected development of numerous bilateral liver mets. Came off trial.
Started Docetaxol/ Herceptin + Zometa.
8/12:Bones stable +major regression in liver (!)
9/12:Can't take any more Docetaxol! Start on Herceptin and Tamoxifen. Cross fingers!
Changed to Denosumab.
11/12: Scan shows stable - yay!
11/13: Still stable :-) !!!
1/16: All stable, but lowered calcium, so switched to Zometa 3 monthly.
2/19: Happily still stable on Herceptin, Letrozole and 3 monthly Zometa.

10-21-2015, 06:04 PM	#1
Pamelamary Senior Member Join Date: Apr 2012 Location: Melbourne, Australia Posts: 494	CoBRA 2015 Interesting conference starts in Melbourne this afternoon, looking at controversies in breast cancer. The medical world so often presents itself as monolithic and beyond challenge, so this should be a welcome change of pace! __________________ Diagnosed 2004: Lumpectomy - 2 tumours, both grade 1 infiltrating duct carcinoma, about 12mm. ER+, C-erbB-2 status 3+. Clear margins, no nodal involvement. Radiotherapy, i year Tamoxifen, 4 years Arimidex. Rediagnosed 2012: Multiple bone metastases. 3/12: began on Marianne trial - T-DM1 + Pertuzamab/Placebo. 5/12:Unexpected development of numerous bilateral liver mets. Came off trial. Started Docetaxol/ Herceptin + Zometa. 8/12:Bones stable +major regression in liver (!) 9/12:Can't take any more Docetaxol! Start on Herceptin and Tamoxifen. Cross fingers! Changed to Denosumab. 11/12: Scan shows stable - yay! 11/13: Still stable :-) !!! 1/16: All stable, but lowered calcium, so switched to Zometa 3 monthly. 2/19: Happily still stable on Herceptin, Letrozole and 3 monthly Zometa.