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Hi Caya,
I, too, know that I metabolize tamoxifen because I had a test done (blood test) that determined I metabolize it properly. But still I wonder if it matters in a Her positve but Pr negative population. If I were as PR positive as you I would not be nearly so concerned. A study from the ASCO 2007 (Dec 2007) pointed out that true triple positives have a better prognosis than the ER positve/Pr negative cohort. So if I were you....I would not be so concerned.
I also agree with you that this is a total crap shoot. Thank goodness Herceptin is out big gun no matter our hormonal status.
Cheers!
Janelle
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Janelle
Diagnosed October 2006 at age 37 wtih grade 3 IDC and high grade DCIS
Stage 1c triple positive, no node involvement but
vascular invasion
multifocal disease
Lumpectomy November, 2006
A/C every 3 weeks (started Jan., 2007 and finished March 2007); followed weekly Taxol (finished June 2007) concurrent with Herceptin (finished March 2008);
Bilateral Mast with immediate recon in Sept 2007; finished recon Dec. 2007
Started 5 years of tamoxifen Nov. 2007; started peptide vaccine clinical trial at MD Anderson October 2008 and finished active part of trial in April 2009 (monthly injections of AE37 peptitde (HLA type specific) with GM-CSF or GM-CSF alone depending on if I was in experimental or control group); started Zometa infusions June 25, 2009- 4mg every 6 months for 3 years (taking it "off-label" to try to prevent mets)
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