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Hello all,
If anyone has info about inheritability of her2+ cancers I'd love to hear it. Of the inherited bc mutations (BRCA 1 or 2) my sense is that they tend to express as ER+ cancers, which her2+ tends NOT to be. So, this is all a big puzzle.
And it's true that her2 plays a function in many cells. One of the reasons for fears about herceptin and cardiotoxicity is that cells in the heart have-and need--her2...
Best,
Jeff
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