HER2 Support Group Forums - View Single Post - High hopes for denosumab-- anti bc metastasis as well as anti bone met properties?

Lani · 02-27-2011, 01:41 AM

again this work was done on mice (which I understand only have er- breast tumors) NOT HUMANS. The results cannot yet be extrapolated to humans

It seems to work particularly well in her2 tumors

The next step is seeing if the effect is the same in human tumors implanted in mice and then after that in human tumors in humans

They might be able to speed it up by doing neoadjuvant tests soon after it shows itself not to make things worse when human tumors are implanted in mice.

Let's hope the research goes quickly as the drug is already approved for two indications.

02-27-2011, 01:41 AM	#9
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: High hopes for denosumab-- anti bc metastasis as well as anti bone met properties again this work was done on mice (which I understand only have er- breast tumors) NOT HUMANS. The results cannot yet be extrapolated to humans It seems to work particularly well in her2 tumors The next step is seeing if the effect is the same in human tumors implanted in mice and then after that in human tumors in humans They might be able to speed it up by doing neoadjuvant tests soon after it shows itself not to make things worse when human tumors are implanted in mice. Let's hope the research goes quickly as the drug is already approved for two indications.