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03-30-2005, 05:04 AM

Hi Roxi1,

Your article made me wonder whether there were any other known CXCR4 antagonists out there. Did a quick search through Pubmed and its seems as though CXCR4 plays a role in alot of diseases, including MS and some AIDS (including the really bad one that was discovered in New York), so there is alot of work going on in this area and even one antagonist that has made it into human trials, (http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15752146). One of the articles linked CXCR5 to central nervous system mets in BC and it would be great to have something that blocked those.

03-30-2005, 05:04 AM	#2
Christine MH Guest Posts: n/a	Hi Roxi1, Your article made me wonder whether there were any other known CXCR4 antagonists out there. Did a quick search through Pubmed and its seems as though CXCR4 plays a role in alot of diseases, including MS and some AIDS (including the really bad one that was discovered in New York), so there is alot of work going on in this area and even one antagonist that has made it into human trials, (http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15752146). One of the articles linked CXCR5 to central nervous system mets in BC and it would be great to have something that blocked those.