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Old 10-13-2019, 03:48 PM   #5
R.B.
Senior Member
 
Join Date: Mar 2006
Posts: 1,813
Re: Cannabinoid receptors main ligands are Omega 3 and 6 derivatives, not hemp prod

I have not read extensively into these topics but just post these by way of examples, of the contention intervention in the Omega 3 and 6 cannabinoid and related pathways might have significant effects - more reading by me and research by scientists in the field required.

Mice are not humans, lab work is not real life, and these things need to be well established, but these historic observations would suggest care, until proven otherwise, would be prudent.

There are certainly plausible generalized pathways for endocrine disruption; intervention in the omega 6 pathways can impact hormone production in utero, including through PGE2 pathways, which could impact gender outlook and physical reproductive organ development, dependent on timing and power of effect on testosterone levels.

This suggests care should be taken, and wider viewpoints considered, when making recommendations as to the usage of THC/CBD products, particularly in females who are pregnant or hoping to get pregnant, and or breast feeding.





Effects of Cannabinoids and Female Exposure on the Pituitary-Testicular Axis in Mice: Possible Involvement of Prostaglandins

https://academic.oup.com/biolreprod/.../2/315/2766959

"Chronic exposure to THC, CBN, or cannabidiol (CBD), beginning at 30 days of age through adulthood, influenced the endocrine responses to a sexually receptive female. Thus, weights of testes and seminal vesicles were reduced in males from all cannabinoid-treated groups on the day after exposure to a female, compared with treated males housed in all-male groups."


"Both psychoactive and nonpsychoactive constitutents of marihuana are capable of altering the function of the pituitary-gonadal axis and of influencing the endocrine responsivity to female-related exteroceptive cues in male mice."



Maternal or Paternal Exposure to Cannabinoids Affects Central Neurotransmitter Levels and Reproductive Function in Male Offspring

https://link.springer.com/chapter/10...59259-710-9_43

"The F1 male offspring of male mice treated with CBN, CBD, or THC presented evidence of reduced fertility and testicular chromosomal abnormalities. In addition, two of the F1 male offspring of the THC-treated mice sired litters containing pups with severe congenital malformations.

These findings indicate that maternal or paternal exposure to cannabinoids can influence developmental and reproductive functions in offspring. Thus, cannabinoids appear to be both mutagenic and teratogenic in mice."

Last edited by R.B.; 10-14-2019 at 10:22 AM..
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