DONALD, HOW ABOUT THIS ONE, NCI AT UNC CHAPPELL HILL LINEBERGER CANCER CENTER IN NORTH CAROLINA.
Protocol No.
LCCC0418Principal InvestigatorSerody, JonathanPhasePhase IIScopeLocalSecondary Protocol No.5-R21-CA105837-01-02TitlePhase II Trial Evaluating the Toxicity and Efficacy of a Multiepitope Dendritic Cell Vaccine Given with Trastuzumab and Vinorelbine for the Treatment of Women with Metastatic Breast Cancer that Express HLA-A0201 and Whose Tumors Overexpress Her-2/NEUApplicable Disease SitesBreast - FemaleDrugs InvolvedDENDRITIC CELL VACCINE
HERCEPTIN
NAVELBINE
TRASTUZUMAB
VINORELBINEStatusOpenParticipating InstitutionsUNC-CHEligibility Document LCCC0418 Eligibility Criteria sig.pdf
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12/14/07 IDC ER- PR- HER2+++ LIVER METS AT DX CONFIRMED BY LIVER BIOPSY
01/14/08 2 AC TREATMENTS-NOT WORKING
02/04/08 13 TAXOL, CARBO, HERCEPTIN TREATMENT-EXCELLENT RESULTS!
05/12/08 HERCEPTIN EVERY 3 WKS
08/22/08 BRAIN METS! 8 <5MM
09/17/08 CYBERKNIFED BRAIN METS
10/20/08 BRAIN METS SHRINKING
12/29/08 BRAIN SCAN SHOWS 1 LESION GONE, 7 SHRINKING & STABLE, 1MM ? SPOT
01/16/09 LIVER REOCUR-XELODA/HERCEPTIN
03/02/09 BRAIN SCAN 2 LESIONS GONE, 5 STABLE, 1MM ? SPOT STILL A ?
3/27/09 REGRESSION OF 2 LIVER LESIONS XELODA & HERCEPTIN
06/08/09 STUPID BRAIN HAS 3 LESIONS
06/29/09 CYBERKNIFE
07/01/09 LIVER REGRESSION NO NEW METS
07/07/09 TYKERB XELODA HERCEPTIN
11/11/09 GEMZAR/HERCEPTIN FOR LIVER PROGRESSION
03/22/10 BRAIN MRI GOOD-3 SMALL NECROSIS LEFT FROM ORIG 11!!
03/26/10 CHANGE TO NAVELBINE/HERCEPTIN 3 LIVER LESIONS PROGRESSING IN SIZE
05/21/10 NAVELBINE/HERCEPTIN WORKING!
07/19/10 GOOD BRAIN MRI
08/20/10 LIVER PROGRESSION
09/08/10 TDM1 - NASHVILLE TN
01/10/11 LIVER RESPONDING TO TDM1
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