[AlaskaAngel]

Hi Jackie07,

Clinical trials for cancer don't always involve taking extreme medications like the ones used for chemotherapy, and I wish more people would take the time to consider helping out by participating.

There are 25 trials listed on clinicaltrials.org by using the search terms Cox2 inhibitor after choosing breast cancer as the disease.... Many are completed trials, and some are not recruiting, but they are still worth considering in trying to find out the results. I won't copy them all here, but they are really interesting. The one that caught my eye (because it is in Seattle and I go there) was the one about Cox2 inhibitors and mammogram density that is offered at Fred Hutch cancer center:

http://clinicaltrials.gov/ct2/show/N...sms%22&rank=22

1Not yet recruiting Perioperative Administration of COX 2 Inhibitors and Beta Blockers to Women Undergoing Breast Cancer Surgery: an Intervention to Decrease Immune Suppression, Metastatic Potential and Cancer Recurrence Condition: Primary Operable Breast CancerIntervention: Drug: Propranolol, etodolac2Active, not recruiting Vinorelbine and Celecoxib in Treating Women With Relapsed or Metastatic Breast Cancer Condition: Breast CancerInterventions: Drug: celecoxib; Drug: vinorelbine ditartrate3Completed A Study of Women With an Early Diagnosis of Breast Cancer, Taking Celecoxib Between the Biopsy and Lumpectomy/Mastectomy Condition: Breast CancerIntervention: Drug: celecoxib 400 mg bid4Active, not recruiting Protocol for Women at Increased Risk of Developing Breast Cancer Condition: Breast CancerInterventions: Drug: celecoxib; Other: placebo5Recruiting Exemestane With Celecoxib as Neoadjuvant Treatment in Postmenopausal Women With Stage II, III, and IV Breast Cancer Condition: Breast CancerInterventions: Drug: Exemestane; Drug: Celecoxib6Completed Celecoxib in Preventing Breast Cancer in At-Risk Premenopausal Women Condition: Breast CancerIntervention: Drug: celecoxib7Completed Biomarkers in Women Receiving Chemotherapy and Celecoxib for Stage II or Stage III Breast Cancer That Can Be Removed by Surgery Condition: Breast CancerInterventions: Biological: filgrastim; Drug: capecitabine; Drug: celecoxib; Drug: cyclophosphamide; Drug: docetaxel; Drug: doxorubicin hydrochloride; Genetic: gene expression analysis; Genetic: polymorphism analysis; Genetic: protein expression analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: imaging biomarker analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Procedure: dynamic contrast-enhanced magnetic resonance imaging; Procedure: needle biopsy; Procedure: neoadjuvant therapy; Procedure: radiomammography; Procedure: ultrasound imaging8Active, not recruiting Celecoxib in Treating Postmenopausal Women Who Are Undergoing Surgery for Invasive Breast Cancer Condition: Breast CancerInterventions: Drug: celecoxib; Procedure: conventional surgery; Procedure: neoadjuvant therapy9Recruiting Study on the Neoadjuvant Use of Chemotherapy and Celecoxib Therapy in Patients With Invasive Breast Cancer Condition: Breast CancerIntervention: Drug: celecoxib and chemotherapy10Recruiting APRiCOT-B: Study to Evaluate Apricoxib in Combination With Lapatinib and Capecitabine in the Treatment of HER2/Neu+ Breast Cancer (TP2001-202) Condition: Breast CancerInterventions: Drug: apricoxib + lapatinib + capecitabine; Drug: placebo + lapatinib + capecitabine11Recruiting The Effect of Aspirin on Angiogenesis Proteins in Women on Tamoxifen Therapy Conditions: Breast Cancer; AngiogenesisIntervention: Drug: Aspirin12Recruiting A Study of the Effects of Inhibiting Platelet Function on Circulating Cancer Cells in Breast Cancer Patients Condition: Breast NeoplasmsInterventions: Drug: Plavix/Aspirin; Other: No Intervention13Active, not recruiting Letrozole and Celecoxib in Treating Postmenopausal Women With Locally Advanced or Metastatic Breast Cancer Condition: Breast CancerInterventions: Drug: celecoxib; Drug: letrozole14Active, not recruiting Exemestane + Celecoxib vs Exemestane + Placebo in Metastatic Breast Cancer Condition: Metastatic Breast CancerInterventions: Drug: placebo; Drug: Celecoxib; Drug: Exemestane15Completed Open-Label Study Of Exemestane With Or Without Celecoxib In Postmenopausal Women With ABC Having Progressed On Tamoxifen Condition: Breast NeoplasmsInterventions: Drug: Celecoxib; Drug: Exemestane16Active, not recruiting Sulindac in Preventing Breast Cancer in Women at High Risk for Breast Cancer Condition: Breast CancerInterventions: Drug: sulindac; Other: laboratory biomarker analysis17Completed Safety, Efficacy and Pharmacokinetic Between Capecitabine and Exisulind in Metastatic Breast Cancer Patients Conditions: Breast Neoplasms; Metastases, NeoplasmInterventions: Drug: Capecitabine; Drug: Exisulind18Completed Celecoxib in Preventing Breast Cancer in Premenopausal Women Condition: Breast CancerInterventions: Drug: celecoxib; Other: placebo19Active, not recruiting Celecoxib in Treating Women With Metastatic or Recurrent Breast Cancer Condition: Breast CancerIntervention: Drug: celecoxib20Completed Celecoxib and Trastuzumab in Treating Women With Metastatic Breast Cancer Condition: Breast CancerInterventions: Biological: trastuzumab; Drug: celecoxibGiven that women are prone to heart disease as well.... and the effects of anti-inflammatory treatment on that... all very interesting.

AlaskaAngel