HER2 Support Group Forums - View Single Post - Genetic differences in enzyme CYP2D6 play a key role in effectiveness of tamoxifen fo

Jasmine · 12-31-2012, 10:00 AM

So.. this most recent study is finding a significant correlation between the gene variant and tamoxifen metabolism? Looking back at the past threads I had interpreted previous studies as not finding a significant correlation? Does this open the door again on CYP2D6 testing, especially for Her2+ populations? My oncologist never mentioned this issue at all, I only learned of the gene alteration from this and other discussion boards. I'm torn on how hard to push for this test as I'm premenopausal and it would open up a Pandora's box of issues if tamoxifen is not an option.

12-31-2012, 10:00 AM	#3
Jasmine Junior Member Join Date: Oct 2012 Location: Maine Posts: 4	Re: Genetic differences in enzyme CYP2D6 play a key role in effectiveness of tamoxife So.. this most recent study is finding a significant correlation between the gene variant and tamoxifen metabolism? Looking back at the past threads I had interpreted previous studies as not finding a significant correlation? Does this open the door again on CYP2D6 testing, especially for Her2+ populations? My oncologist never mentioned this issue at all, I only learned of the gene alteration from this and other discussion boards. I'm torn on how hard to push for this test as I'm premenopausal and it would open up a Pandora's box of issues if tamoxifen is not an option.