One of the brochures on Joe's link actually tells docs exactly what to do and when... (It shows pics that I don't know how to transfer over, but I have transcribed the info
*Employ a proactive approach in managing skin reactions.
*Suggest that patients use a thick, alcohol-free emollient cream.
*Suggest that patients use a sunscreen of SPF 25 or higher, preferably
containing zinc oxide or titanium dioxide
* If patient presents with rash, verify appropriate administration of drug and proceed with the following therapy algorithm:
Mild:
Minimally located
No impact on activities of daily life (ADL)
No sign of superinfection
(shows picture of mild rash occurrence across bridge of nose and cheeks)
Continue EGFR targeted treatment @current dose and monitor for change in severity.
***Use:
Topical hydrocortisone 1% or 2.5% cream and/or Clindamycin 1% gel
Reassess after 2 weeks, if reaction worsens or does not improve, proceed to next step.
_____________
Moderate:
Generalized
Mild Symptoms (e.g. pruritus, tenderness)
Minimal impact on ADL
No sign of superinfection
(shows picture of red worsened rash occurrence (pruritus) across nose, around nostrils, top lip, lower cheeks, and entire chin.)
Continue EGFR targeted treatment @current dose and monitor for change in severity. Continue treatment of the skin reaction with the following:
***Use:
Hydrocortisone 2.5% cream or Clindamycin 1% gel
or Pimecrolimus 1% cream
Plus Doxycycline 100mg BID or Monocycline 100mg BID
Reassess after 2 weeks, if reaction worsens or does not improve, proceed to next step.
________________
Severe:
Generalized
Severe symptoms (e.g. pruritus, tenderness)
Significant impact on ADL
Potential sign of superinfection
(shows picture of worsened rash occurrence similar to moderate with more facial coverage and continuation to shoulders and neck)
Reduce EGFR targeted therapy as per label and monitor for change in severity. Continue treatment of skin reaction with the following:
***Use:
Hydrocortisone 2.5% cream or Clindamycin 1% gel
or Pimecrolimus 1% cream
Plus Doxycycline 100mg BID or Monocycline 100mg BID
Plus Medrol dose pack
Reassess after 2 weeks, if reaction worsens, dose interruption or discontinuation may be necessary.