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Karina,
If it was beyond doubt that DCA is safe, it would be the ideal drug to try as an alkalizing agent in fighting cancer since it has been used to treat acidosis. And I dearly hope, whatever the mode of action of DCA is, that the rat experiments at the University of Alberta will be translated into safe human treatments.
But at this time, reading about some of the past preclinical (on dogs) & clinical trials (on patients with acidosis) is rather scary. Permanent neurological damage (including paralysis) & deaths were frequent at doses in the 50mg/kg or more range.
The Alberta tests were done at higher doses, & they do not report side effects as bad as this. So may be they have found a way to minimize them.
Or perhaps the victims of acidosis & dogs are particularly vulnerable to the side effects of DCA. An other possibility is that these past experiments were chronic relatively long term treatments & side effects reflected the cummulative impact. If DCA works quickly in the case of cancer, then side
effects may not reach untolerable levels.
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