Re: Mekinist (Trametinib) a MEK Kinase inhibitor
I dont want to leave things incomplete so I studied BRAF
mutation. Actually it involves that RAF-RAS- MEK-ERK signalling. BRAF is actually B-RAF so it is a RAF protein that has been mutated with a single amino acid substitution. This single amino acid substitution creates a more active RAF so the RAS-RAF-MEK-ERK pathway becomes hyperactive with increased cancer cell growth.
Paul
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