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FilY · 10-11-2016, 01:02 AM

No, TDM1 is a large molecule that does NOT cross the BBB. Thus another technique is needed to prevent brain mets. I recently shifted from Herceptin to TDM1 as a result of what might (not certain) have been early signs of progression. While on Herceptin I was also using Tykerb (lapatinib) which DOES cross the BBB, especially with a pulsed dosing regimen. However Tykerb appears to be incompatible with TDM1 so I'm looking for an alternative. See post of my history and experimental treatment with Tykerb here.

10-11-2016, 01:02 AM	#3
FilY Member Join Date: Aug 2016 Posts: 5	Re: Does TDM1 cross blood brain barrier No, TDM1 is a large molecule that does NOT cross the BBB. Thus another technique is needed to prevent brain mets. I recently shifted from Herceptin to TDM1 as a result of what might (not certain) have been early signs of progression. While on Herceptin I was also using Tykerb (lapatinib) which DOES cross the BBB, especially with a pulsed dosing regimen. However Tykerb appears to be incompatible with TDM1 so I'm looking for an alternative. See post of my history and experimental treatment with Tykerb here.