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Becky · 02-23-2010, 05:33 PM

Dear Melissa

There is currently a trial comparing the three AIs in early bc. There have been some very,very small studies comparing them to women who have metastatic disease. In one of these studies, Femara was slightly better but the study population was so small it wasn't statistically significant. You need a huge population.

That said, the best one is the one that gives you the most tolerable side effects (if any). So if Aromisin is the best, great - but if you feel worse than you did on Femara, then maybe switch back.

Try taking the drug at night right before bed. It might help with some of the side effects which might be worse in the first 7-8 hours you are on it and you would be fast asleep.

02-23-2010, 05:33 PM	#3
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: comparing AI'S Dear Melissa There is currently a trial comparing the three AIs in early bc. There have been some very,very small studies comparing them to women who have metastatic disease. In one of these studies, Femara was slightly better but the study population was so small it wasn't statistically significant. You need a huge population. That said, the best one is the one that gives you the most tolerable side effects (if any). So if Aromisin is the best, great - but if you feel worse than you did on Femara, then maybe switch back. Try taking the drug at night right before bed. It might help with some of the side effects which might be worse in the first 7-8 hours you are on it and you would be fast asleep. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"