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Re: Metformin, anything new?
Ill research this for you. Logically it doesnt make sense but pharmacology isnt always logical. For instance pts with colon cancer given 800mg Cimetidine daily starting 2 weeks before surgery had twice the 10 year survival of those not getting Cimetidine. Cimetidine is a Histamine 2 receptor blocker. So is Ranitidine (Zantac) and there are others. Logically all Histmaine h2 blockers should have this life extending effect in colon cancer but it seems only Cimetidine (Tagamet) does.
Metformin has action against stem cells and Im sure ER- breast cancer cells form stem cells. Metformin decreases insulin resistance and decreases serum Insulin and probably Insulin growth factor so should have an anti-cancer action, at least in theory. The anti-cancer action of Metformin involves activation oof AMPK kinase and decrease M-Tor action. I didnt realize the estrogen receptor was that involved in the situation. Ill check this out. By the way brocolli has an anticancer substane in it ie Indole-Carboxamide or something like that. Its hard to keep these things in your head
Paul
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