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Rich66 · 11-01-2009, 04:23 PM

*might not be compatible with chemo etc.

Pomegranate fruit extract impairs invasion and motility in human breast cancer
Integrative Cancer Therapies , 10/12/09

Khan GN et al. – Inhibition of motility and invasion by PFEs, coincident with suppressed RhoC and RhoA protein expression, suggests a role for these defined extracts in lowering the metastatic potential of aggressive breast cancer species.
Methods

Investigated effect of novel, defined PFE consisting of both fermented juice and seed oil on NF-kB pathway, which is constitutively active in aggressive breast cancer cell lines
Effects of PFE on NF-kB—regulated cellular processes such as cell survival, proliferation, and invasion also examined

Results

Analytical characterization of bioactive components of PFE revealed active constituents, mainly ellagitannins and phenolic acids in aqueous PFE and conjugated octadecatrienoic acids in lipid PFE derived from seed
Aqueous PFE dose-dependently inhibited NF-kB—dependent reporter gene expression associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression

11-01-2009, 04:23 PM	#1
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Pomegranate fruit extract impairs invasion and motility in human breast cancer might not be compatible with chemo etc. Pomegranate fruit extract impairs invasion and motility in human breast cancer Integrative Cancer Therapies , 10/12/09 Print Email This Article Save in My Library Free Abstract Khan GN et al. – Inhibition of motility and invasion by PFEs, coincident with suppressed RhoC and RhoA protein expression, suggests a role for these defined extracts in lowering the metastatic potential of aggressive breast cancer species. Methods* Investigated effect of novel, defined PFE consisting of both fermented juice and seed oil on NF-kB pathway, which is constitutively active in aggressive breast cancer cell lines Effects of PFE on NF-kB—regulated cellular processes such as cell survival, proliferation, and invasion also examined Results Analytical characterization of bioactive components of PFE revealed active constituents, mainly ellagitannins and phenolic acids in aqueous PFE and conjugated octadecatrienoic acids in lipid PFE derived from seed Aqueous PFE dose-dependently inhibited NF-kB—dependent reporter gene expression associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression __________________ Mom's treatment history (link)