[Jackie07]

Janis,

The latest abstract I could locate on the subject was published in 2002. Seems it's a recognized fact ... Doctors must have had a lot of experience on the procedure by now. Hope you will get the problem solved soon.

Arch Ophthalmol. 2002 Sep;120(9):1180-2.
Docetaxel secretion in tears: association with lacrimal drainage obstruction.

Esmaeli B, Ahmadi MA, Rivera E, Valero V, Hutto T, Jackson DM, Newman RA.
Source

Ophthalmology Section, Department of Plastic Surgery, Box 443, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. besmaeli@mdanderson.org

Abstract

OBJECTIVE:

To test the hypothesis that docetaxel may be secreted in tears after intravenous infusion.
DESIGN:

Prospective pilot trial.
PATIENTS AND METHODS:

Tear fluid was collected from 4 patients receiving docetaxel weekly and 2 patients receiving docetaxel every 3 weeks as a single agent for the treatment of metastatic breast cancer. Tear samples were collected once prior to and again within 30 minutes following the end of the 1-hour docetaxel infusion. A blood sample was also obtained after infusion. The tear and plasma samples were analyzed for drug content using high-performance liquid chromatography and tandem mass spectrometry.
RESULTS:

Docetaxel was found in the tear samples collected from all 6 patients.
CONCLUSION:

The secretion of docetaxel in tears may be a mechanism for canalicular inflammation and tear drainage obstruction, which are known to occur as an adverse effect of the drug.