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Old 05-17-2015, 08:27 PM   #5
annettchen
Senior Member
 
Join Date: Mar 2014
Posts: 95
Re: How soon to know if Kadcyla/TDM-1 is working?

I have a limited number of bone mets. My markers (CA15-3 and CEA) and all bloodwork except LDH and Calcium are normal. LDH and Calcium was slightly elevated in the first 3 months of treatment, normal since. But when I had the first check after going on Taxotere, Herceptin and Perjeta in early summer last year, my onc almost took me off and moved me on to T-DM1 because the radiologist claimed progression. Luckily (because of completely normal bloodwork and my feeling quite well - considering I was on a taxane) she double-checked in the tumor conference, and I sent copies of all scans and bloodwork to another more experienced onc as well. It was deemed a "flare-up". There was no progression. I finished the combo and have been on Herceptin / Pertuzumab / Xgeva only and stable since. All that they see now in the scans is bone scarring. Still nothing anywhere else. Keeping fingers crossed...
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Annette
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03/2014: Diagnosed with ER/PR-, HER2+++ MBC (bone mets, oligometastatic)
04/2014: Started 6 cycles of "PHD" (Perjeta, Herceptin, Docetaxol)
07/2014: Finished 6 cycles of PHD; restaging; 2 bone mets are sclerotic - looks like Herceptin and Perjeta is working
10/2014: STABLE!
01/2015: STABLE!
04/2015: STABLE!
08/2015: STABLE!
12/2015: BRAIN METS. BODY STABLE.
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