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Hi just read where COX 2 Celebrex together with Aromasin works better than Aromasin on its own so probably the same with Tamoxefin.
COX-2 and aromatase are two different enzymes that are naturally produced by the body. Enzymes are special proteins that help the body's normal chemical reactions. But they can also promote the growth of breast cancer by increasing the amount of certain chemicals in the body. Separate studies have found that drugs that block the production of aromatase (called aromatase inhibitors) and drugs that block the production of COX-2 (called COX-2 inhibitors) are effective in slowing down the growth of breast cancer. Studies in rats have also found that a combination of the aromatase inhibitor Aromasin (chemical name: exemestane) and the COX-2 inhibitor Celebrex (chemical name: celecoxib) is better at slowing the growth of breast cancer than either drug used alone. In a study presented at ASCO 2003, researchers looked at whether these drugs might also work well together in post-menopausal women with advanced (metastatic) hormone-receptor-positive disease. The researchers gave Aromasin to a small group of women with this type of breast cancer, some of whom also were given Celebrex.
Hugs Lyn
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