|
Not sure if this has been highlighted recently but its worth reading.
"Moreover COX-2 enzymatic inhibition dramatically reduced HER-2 protein levels efficiently increased the cancer cells sensitility to chemotherapeutic treatment and acted in synergy with HER-2 inhibitor trastuzumab. Therefore we propose an original model where HER-2 and COX-2 transcriptionally regulate each other in a positive loop."
|