[Diane H]

Have been on weekly herceptin for four months, have decided to switch to every three week regime. My onc fine with this but onc on duty the day I actually switched felt he needed to inform me that if I was his patient he would not allow me to go to the three week dosing as he felt it increased cardiotoxicity and had not been used in a trial. I thought it had been part of the three arm trial just recently ended due to the great results. I asked him where I could find the information that he was quoting as to increased toxicity with the three week and he basically ended the conversation. So what I'd like to know has anyone done trials with three week dosing and are you aware of any problems with it---