HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 09-11-2008, 02:25 PM

Hi T Sund

Here is a link for celecoxib.

http://en.wikipedia.org/wiki/Celebrex

I cannot in any way give advice on specific conditions in relation to individual circumstances. I have no training to do so. I can only draw your attention to the generality of relevant trials for your consideration.

Omega 3 and 6 do impact on the immune function through a number of mechanisms. IF there is dietary excess of Omega 6 and a lack of Omega 3 fats from plant sources (eg vegetable oils) AND a lack of long chain Omega 3s DHA and EPA or blocked conversion pathways there is significant evidence this can negatively impact on the immune function.

As posted already there is some evidence that increasing the intake of long chain omega 3s may help in some circumstances with fatigue etc.

These are listed as symptoms of CFS

http://www.spineuniverse.com/display...rticle155.html

Symptoms of Fibromyalgia include:

—Multiple tender points and muscle pain

—Disturbed sleep with morning fatigue and stiffness

—Aggravation of signs and symptoms by modulating factors (emotional stress, temperature changes)

—Subjective swelling and numbness

—Chronic headaches

—Irritable bowel syndrome

—Cold intolerance (Raynaud's Phenomenon)

—Dysmenorrhea - painful menstruation

—Exercise intolerance

—Weakness

A number of them have also been linked at some level with Omega 3:6 imbalances.

A search under leukemia or CFS and DHA or Omega 3 etc on Pubmed http://www.ncbi.nlm.nih.gov/ will produce some trials.

CFS
There are a few for CFS. This is an example suggesting CFS sufferers have a lack of Omega 3 and excess Omega 6

Neuro Endocrinol Lett. 2005 Dec;26(6):745-51.Links
In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.
Maes M, Mihaylova I, Leunis JC.

M-Care4U Outpatient Clinics, and the Clinical Research Center for Mental Health, Antwerp, Belgium.

ABSTRACT

"There is now evidence that major depression is accompanied by decreased levels of omega3 poly-unsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). There is a strong comorbidity between major depression and chronic fatigue syndrome (CFS). The present study has been carried out in order to examine PUFA levels in CFS. In twenty-two CFS patients and 12 normal controls we measured serum PUFA levels using gas chromatography and mass spectrometry. We found that CFS was accompanied by increased levels of omega6 PUFAs, i.e. linoleic acid and arachidonic acid (AA), and mono-unsaturated fatty acids (MUFAs), i.e. oleic acid. The EPA/AA and total omega3/omega6 ratios were significantly lower in CFS patients than in normal controls. The omega3/omega6 ratio was significantly and negatively correlated to the severity of illness and some items of the FibroFatigue scale, i.e. aches and pain, fatigue and failing memory. The severity of illness was significantly and positively correlated to linoleic and arachidonic acid, oleic acid, omega9 fatty acids and one of the saturated fatty acids, i.e. palmitic acid. In CFS subjects, we found significant positive correlations between the omega3/omega6 ratio and lowered serum zinc levels and the lowered mitogen-stimulated CD69 expression on CD3+, CD3+ CD4+, and CD3+ CD8+ T cells, which indicate defects in early T cell activation. The results of this study show that a decreased availability of omega3 PUFAs plays a role in the pathophysiology of CFS and is related to the immune pathophysiology of CFS. The results suggest that patients with CFS should respond favourably to treatment with--amongst other things- --omega3 PUFAs, such as EPA and DHA."

http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

So have a look at some more.

LEUKEMIA

There has been some work in the area of leukemia which seems to suggest possible benefits for EPA for example or usage as a treatment adjunct.

http://www.ncbi.nlm.nih.gov/sites/en...20%20omega%203

GOOD CLINICAL BOOK ON ACUTE INFLAMMATION

This is expensive but an excellent book you could give to your doctor. It is rare in being clinically orientated It is a powerful book. It is not an easy read but your friend just needs to get the jist and give it to her doctor as a basis for dietary discussion.

Omega 3 Fatty Acids in Clinical Nutrition by Heller, Stehr and Koch.

AND FINALLY

Your friend must tell to her doctor before any significant change in diet. I would suggest doing some more reading on Omega 3 and 6 and CFS etc printing the information and taking it to the doctor at the time of visit.

09-11-2008, 02:25 PM	#263
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Hi T Sund Here is a link for celecoxib. http://en.wikipedia.org/wiki/Celebrex I cannot in any way give advice on specific conditions in relation to individual circumstances. I have no training to do so. I can only draw your attention to the generality of relevant trials for your consideration. Omega 3 and 6 do impact on the immune function through a number of mechanisms. IF there is dietary excess of Omega 6 and a lack of Omega 3 fats from plant sources (eg vegetable oils) AND a lack of long chain Omega 3s DHA and EPA or blocked conversion pathways there is significant evidence this can negatively impact on the immune function. As posted already there is some evidence that increasing the intake of long chain omega 3s may help in some circumstances with fatigue etc. These are listed as symptoms of CFS http://www.spineuniverse.com/display...rticle155.html Symptoms of Fibromyalgia include: —Multiple tender points and muscle pain —Disturbed sleep with morning fatigue and stiffness —Aggravation of signs and symptoms by modulating factors (emotional stress, temperature changes) —Subjective swelling and numbness —Chronic headaches —Irritable bowel syndrome —Cold intolerance (Raynaud's Phenomenon) —Dysmenorrhea - painful menstruation —Exercise intolerance —Weakness A number of them have also been linked at some level with Omega 3:6 imbalances. A search under leukemia or CFS and DHA or Omega 3 etc on Pubmed http://www.ncbi.nlm.nih.gov/ will produce some trials. CFS There are a few for CFS. This is an example suggesting CFS sufferers have a lack of Omega 3 and excess Omega 6 Neuro Endocrinol Lett. 2005 Dec;26(6):745-51.Links In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Maes M, Mihaylova I, Leunis JC. M-Care4U Outpatient Clinics, and the Clinical Research Center for Mental Health, Antwerp, Belgium. ABSTRACT "There is now evidence that major depression is accompanied by decreased levels of omega3 poly-unsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). There is a strong comorbidity between major depression and chronic fatigue syndrome (CFS). The present study has been carried out in order to examine PUFA levels in CFS. In twenty-two CFS patients and 12 normal controls we measured serum PUFA levels using gas chromatography and mass spectrometry. We found that CFS was accompanied by increased levels of omega6 PUFAs, i.e. linoleic acid and arachidonic acid (AA), and mono-unsaturated fatty acids (MUFAs), i.e. oleic acid. The EPA/AA and total omega3/omega6 ratios were significantly lower in CFS patients than in normal controls. The omega3/omega6 ratio was significantly and negatively correlated to the severity of illness and some items of the FibroFatigue scale, i.e. aches and pain, fatigue and failing memory. The severity of illness was significantly and positively correlated to linoleic and arachidonic acid, oleic acid, omega9 fatty acids and one of the saturated fatty acids, i.e. palmitic acid. In CFS subjects, we found significant positive correlations between the omega3/omega6 ratio and lowered serum zinc levels and the lowered mitogen-stimulated CD69 expression on CD3+, CD3+ CD4+, and CD3+ CD8+ T cells, which indicate defects in early T cell activation. The results of this study show that a decreased availability of omega3 PUFAs plays a role in the pathophysiology of CFS and is related to the immune pathophysiology of CFS. The results suggest that patients with CFS should respond favourably to treatment with--amongst other things- --omega3 PUFAs, such as EPA and DHA." http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum So have a look at some more. LEUKEMIA There has been some work in the area of leukemia which seems to suggest possible benefits for EPA for example or usage as a treatment adjunct. http://www.ncbi.nlm.nih.gov/sites/en...20%20omega%203 GOOD CLINICAL BOOK ON ACUTE INFLAMMATION This is expensive but an excellent book you could give to your doctor. It is rare in being clinically orientated It is a powerful book. It is not an easy read but your friend just needs to get the jist and give it to her doctor as a basis for dietary discussion. Omega 3 Fatty Acids in Clinical Nutrition by Heller, Stehr and Koch. AND FINALLY Your friend must tell to her doctor before any significant change in diet. I would suggest doing some more reading on Omega 3 and 6 and CFS etc printing the information and taking it to the doctor at the time of visit. Last edited by R.B.; 09-11-2008 at 03:48 PM..