|
Terri,
Fasolodex (Fulvestrant) is used as a second-line treatment for those who fail on an initial AI. My onc did not suggest it, but would have considered my request if I asked for it. I am not thrilled with the method of action, i.e., degradation of the estrogen receptor, as I understand it would degrade the receptors of cells where we want them (i.e., genetalia) in addition to cells where we don't want them (i.e., breast cancer cells). What researchers are finding is that cells which become hypersensitive to estrogen through the estrogen withdrawl that occurs with AI's are capable of being killed by large doses of estrogen once they stop responding to the AI's. I don't see how that would work if your cells no longer had estrogen receptors.
Again, this is all just my personal opinion (and my personal reasons for my preference for an AI) and take on things. I am not a medical professional.
Hopeful
|